Patients should be warned against interruption or discontinuation of therapy without the physician's advice. If angina markedly worsens or acute coronary insufficiency develops, metoprolol tartrate administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. The dosage should be gradually reduced over a period of 1 to 2 weeks and the patient should be carefully monitored when discontinuing chronic therapy. Warn patients not to interrupt or discontinue therapy without physician advice.įollowing abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. If angina markedly worsens or acute coronary insufficiency develops, reinstate administration promptly, at least temporarily, and take other measures appropriate for the management of unstable angina. When discontinuing chronic therapy, gradually reduce the dose over a period of 1 to 2 weeks and monitor the patient carefully. Exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred after abrupt cessation of therapy with certain beta-blocking agents.
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